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The delineated zone runs from a western boundary drawn between Iran's Qeshm Island and the UAE's Umm al Quwain, and extends eastward to a line connecting Iran's Mount Mobarak with Fujairah in the UAE.
The UAE Defence Ministry said Iran had launched four cruise missiles, with three shot down and one falling into the sea. Authorities in the eastern emirate of Fujairah said an Iranian drone sparked a fire at a key oil facility.
Negotiations between Washington and Tehran have been deadlocked since a ceasefire in the US-Israeli war against Iran took effect on April 8, with Tehran's stranglehold on the strait a main point of contention.
There had been "no casualties to date" among the 24 crew members on board, who include six South Koreans and 18 foreign nationals, the ministry said in a statement.