Cyanide & Happiness began as a small series of comics drawn by Kris Wilson. It was eventually showcased on the Comicaze website, and then on Sticksuicide.com, "a website devoted to animations and games graphically depicting the violent deaths of stick figures", which was founded by Rob DenBleyker in 2004.
The cartoonists regularly make jokes on controversial topics including abortion, suicide, and AIDS. Their characters rarely have names and are usually only distinguishable by the colors of their shirts. The male characters almost always have no hair. Female characters are distinguishable by their long hair and chest size, often used to comedic effect.
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